Journal
APPLIED SURFACE SCIENCE
Volume 253, Issue 19, Pages 7755-7760Publisher
ELSEVIER
DOI: 10.1016/j.apsusc.2007.02.085
Keywords
drug delivery; polysaccharide; pullulan derivatives; thin films; matrix assisted pulsed laser evaporation
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We have demonstrated the successful thin film growth of two pullulan derivatives (cinnamate-pullulan and tosylate-pullulan) using matrix assisted pulsed laser evaporation (MAPLE). Our MAPLE system consisted of a KrF* laser, a vacuum chamber, and a rotating target holder cooled with liquid nitrogen. Fused silica and silicon (I 1 1) wafers were used as substrates. The MAPLE-deposited thin films were characterized by transmission spectrometry, profilometry, atomic force microscopy (AFM), Fourier transform infrared (FTIR) spectroscopy and Raman spectroscopy. The deposited layers ranged from 250 nm to 16.5 mu m in thickness, depending on the laser fluence (0.065-0.5 J cm(-2)) and number of pulses applied for the deposition of one structure (1500-13,300). Our results confirmed that MAPLE was well-suited for the transfer of cinnamate-pullulan and tosylate-pullulan. (c) 2007 Elsevier B.V. All rights reserved.
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