Journal
ANALYTICAL BIOCHEMISTRY
Volume 386, Issue 2, Pages 293-295Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ab.2008.12.019
Keywords
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Funding
- Korean Research Foundation Grant
- Korean Government [KRF-2008-C00740]
- Ajou University (2008-General Subjects)
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The slow process required for alpha-synuclein to form amyloid fibrils is a major obstacle in the development of therapeutic compounds for alpha-synuclein-related neurodegenerative diseases such as Parkinson's disease (PD). Here we have developed an efficient method by which amyloid fibrils can be formed from alpha-synuclein using ionic liquids (ILs). This report indicates that ILs could potentially be used as a stimulator for the amyloid formation of alpha-synuclein. (C) 2008 Elsevier Inc. All rights reserved.
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