4.7 Article

Domino hydroformylation/enantioselective cross-aldol addition

Journal

ADVANCED SYNTHESIS & CATALYSIS
Volume 349, Issue 11-12, Pages 1891-1895

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.200700216

Keywords

aldol reaction; asymmetric synthesis; domino reactions; homogeneous catalysis; hydroformylation; organocatalysis

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A domino hydroformylation/enantioselective cross-aldol reaction sequence is reported. Starting from simple alkenes enantiomerically pure aldol addition products, which represent valuable building blocks for polypropionate construction, can be obtained in a one-pot operation.

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