Journal
JOURNAL OF BONE AND MINERAL RESEARCH
Volume 22, Issue 8, Pages 1271-1279Publisher
AMER SOC BONE & MINERAL RES
DOI: 10.1359/JBMR.070506
Keywords
aging; IGF-I; receptor; osteoblast; mouse
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IGF-I plays an important anabolic role in stimulating bone formation and maintaining bone mass. We show that the pro-proliferative, anti-apoptotic, and functional responses to IGF-I in bone and BMSCs decrease with aging. These changes are associated with impaired receptor activation and signal transduction through the MAPK and PI3K pathways.
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