Journal
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
Volume 31, Issue 5, Pages 271-276Publisher
ELSEVIER
DOI: 10.1016/j.ejps.2007.04.002
Keywords
polymorphism; crystallisation; amorphous materials; paracetamol
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We have been able to isolate and study the polymorphic form III of paracetamol using a specially designed methodology. Our work represents the first report of a reproducible, reliable route to form III. This has been an outstanding problem for over quarter of a century. Our method may be applicable to the isolation of metastable polymorphs of other compounds. (c) 2007 Elsevier B.V. All rights reserved.
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