Journal
HAEMATOLOGICA
Volume 92, Issue 8, Pages 1127-1130Publisher
FERRATA STORTI FOUNDATION
DOI: 10.3324/haematol.11288
Keywords
Fc gamma R polymorphisms; follicular lymphoma; BCL2/IgH rearrangements
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Funding
- Associazione Italiana per la Ricerca contro il Cancro (AIRC)
- Consiglio Nazionale per le Ricerche (CNR) [CU 03.00357]
- Ministero dell'Istruzione Universita e Ricerca (MIUR)
- Associazione Paolo Belli
- Associazione Italiana Lotta alla Leucemia (AIL), sezione Paolo Belli
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We analyzed Fc gamma RIIIA-158V/F and Fc gamma RIIA-131H/R polymorphisms in a cohort of 94 newly diagnosed follicular lymphoma (FL) patients sequentially treated with CHOP and Rituximab. With a median follow-up of 5.8 years, the overall survival at 8 years is 83%. Univariate and multivariate analysis showed no correlation between Fc gamma RIIIA-158VV/VF and Fc gamma RIIA-131HH/HR polymorphisms and the overall response rate, the molecular response and the event-free survival obtained after CHOP and Rituximab. By contrast, the achievement of a durable molecular clearance of BCL2/IgH(+) cells detectable in the bone marrow is confirmed to be a reliable predictive factor of a better long-term clinical outcome.
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