Journal
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
Volume 1773, Issue 8, Pages 1311-1340Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbamcr.2007.05.003
Keywords
mitogen_activated protein kinase; MAPK; Fus3; Kss1; Hog1; Mpk1/Slt2; Smk1; mitogen_activated protein kinase kinase; MAPKK; Ste7; Pbs2; Mkk1; Mkk2; mitogen_activated protein kinase kinase kinase; MAPKKK; Ste11; Ssk2; Ssk22; Bck1; mitogen_activated protein kinase kinase kinase kinase; MAPKKKK; Pkc1; P21_activated protein kinase; PAK; Ste20; 5'_AMP_activated protein kinase; AMPK; Snf1; 3',5'_cyclic AMP_dependent protein kinase; PKA; Tpk1; Tpk2; Tpk3; pheromone response; filamentous growth response; hyperosmotic stress response; cell wall integrity; signaling; meiosis and sporulation; signal transduction mechanisms; signal propagation; signaling fidelity; spatial and temporal regulation; yeast; Saccharomyces cerevisiae; Baker's yeast; budding yeast
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Funding
- NIGMS NIH HHS [T32 GM007232, R01 GM021841-33, R01 GM021841, GM07232, GM21841] Funding Source: Medline
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Signaling pathways that activate different mitogen-activated protein kinases (MAPKs) elicit many of the responses that are evoked in cells by changes in certain environmental conditions and upon exposure to a variety of hormonal and other stimuli. These pathways were first elucidated in the unicellular eukaryote Saccharomyces cerevisiae (budding yeast). Studies of MAPK pathways in this organism continue to be especially informative in revealing the molecular mechanisms by which MAPK cascades operate, propagate signals, modulate cellular processes, and are controlled by regulatory factors both internal to and external to the pathways. Here we highlight recent advances and new insights about MAPK-based signaling that have been made through studies in yeast, which provide lessons directly applicable to, and that enhance our understanding of, MAPK-mediated signaling in mammalian cells. (C) 2007 Elsevier B.V. All rights reserved.
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