Journal
PEPTIDES
Volume 28, Issue 8, Pages 1527-1531Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.peptides.2007.07.007
Keywords
amphibian; antimicrobial peptide; Odorrana grahami; Helicobacter pylori
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An antimicrobial peptide named odorranain-HP was identified from skin secretions of the diskless odorous frog, Odorrana grahami. It is composed of 23 amino acids with an amino acid sequence of GLLRASSVWGRKYYVDLAGCAKA. By BLAST search, odorranain-HP had similarity to antimicrobial peptide odorranain-W1 but it has a different GLLR N-terminus. The cDNA encoding odorranain-HP was cloned from the cDNA library of the skin of O. grahami. This peptide showed antimicrobial activities against tested microorganisms. Interestingly, odorranain-HP could exert antimicrobial capability against Helicobacter pylori, along with its antimicrobial activities similar to odorranain-W1. This is the first report of naturally occurring peptide with anti-H. pylori activity from amphibian skins. (c) 2007 Elsevier Inc. All rights reserved.
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