Journal
HEART RHYTHM
Volume 4, Issue 8, Pages 1034-1045Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.hrthm.2007.04.015
Keywords
arrhythmia; border zone; conduction velocity; infarction; mapping; MRI; propagation; ventricular tachycardia
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Funding
- Intramural NIH HHS [Z01 HL004609-04] Funding Source: Medline
- NHLBI NIH HHS [Z01-HL4004609, P01 HL030557-200007, P01 HL030557, HL30557] Funding Source: Medline
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BACKGROUND Infarct border zone (IBZ) geometry Likely affects inducibility and characteristics of postinfarction reentrant ventricular tachycardia, but the connection has not been established. OBJECTIVE The purpose of this study was to determine characteristics of postinfarction ventricular tachycardia in the IBZ. METHODS A geometric model describing the relationship between IBZ geometry and wavefront propagation in reentrant circuits was developed. Based on the formulation, slow conduction and block were expected to coincide with areas where IBZ thickness (T) is minimal and the Local spatial gradient in thickness (Delta T) is maximal, so that the degree of wavefront curvature rho proportional to Delta T/T is maximal. Regions of fastest conduction velocity were predicted to coincide with areas of minimum Delta T. In seven arrhythmogenic postinfarction canine heart experiments, tachycardia was induced by programmed stimulation, and activation maps were constructed from multichannel recordings. IBZ thickness was measured in excised hearts from histologic analysis or magnetic resonance imaging. Reentrant circuit properties were predicted from IBZ geometry and compared with ventricular activation maps after tachycardia induction. RESULTS Mean IBZ thickness was 231 +/- 140 Am at the reentry isthmus and 1440 +/- 770 Am in the outer pathway (P < 0.001). Mean curvature p was 1.63 +/- 0.45 mm(-1) at functional block line Locations, 0.71 +/- 0.18 mm(-1) at isthmus entrance-exit points, and 0.33 +/- 0.13 mm(-1) in the outer reentrant circuit pathway. The mean conduction velocity about the circuit during reentrant tachycardia was 0.32 +/- 0.04 mm/ms at entrance-exit points, 0.42 +/- 0.13 mm/ms for the entire outer pathway, and 0.64 +/- 0.16 mm/ms at outer pathway regions with minimum Delta T. Model sensitivity and specificity to detect isthmus Location was 75.0% and 97.2%. CONCLUSIONS Reentrant circuit features as determined by activation mapping can be predicted on the basis of IBZ geometrical relationships.
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