Journal
JOURNAL OF NATURAL PRODUCTS
Volume 70, Issue 8, Pages 1321-1328Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np070101b
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Funding
- NCI NIH HHS [CA44848] Funding Source: Medline
- NCRR NIH HHS [S10RR017768] Funding Source: Medline
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Four new 3-methyl-4-ethylideneproline-containing peptides, lucentamycins A-D (1-4), have been isolated from the fermentation broth of a marine-derived actinomycete identified by phylogenetic methods as Nocardiopsis lucentensis (strain CNR-712). The planar structures of the new compounds were assigned on the basis of 1D and 2D NMR spectroscopic techniques, while the absolute configurations of the amino acid residues were determined by application of the advanced Marfey method. Lucentamycins A (1) and B (2) showed significant in vitro cytotoxicity against HCT-116 human colon carcinoma.
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