Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 349, Issue 11-12, Pages 1949-1954Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.200700026
Keywords
fragrances; Heck reaction; one-pot reaction; palladium; raspberry scent; supported catalysts
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The one-pot synthesis of the fragrance 4(p-methoxyphenyl)butan-2-one, with raspberry scent, has been carried out using palladium on different supports such as magnesium oxide (MgO), hydrotalcite, hydroxyapatite (HA), aluminium oxide (gamma-Al2O3) and titanium dioxide (TiO2). The first pathway consists of a Heck coupling between 4-methoxyiodoanisole and methyl vinyl ketone followed by hydrogenation. Palladium supported on titanium di-oxide showed the best performance for carrying out both consecutive steps giving 4-(p-methoxyphenyl)butan-2-one with high yields and selectivity. The Pd-TiO2 catalyst is more active than a homogeneous palladium complex that is well accepted in the literature as being highly active for performing Heck reactions.
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