Journal
INTERNATIONAL JOURNAL OF NEURAL SYSTEMS
Volume 17, Issue 4, Pages 319-327Publisher
WORLD SCIENTIFIC PUBL CO PTE LTD
DOI: 10.1142/S0129065707001160
Keywords
Parkinson's disease; dopamine; reciprocal inhibition; spinal cord; rigidity; neural model
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It is suggested that co-contraction. of antagonist motor units perhaps due to abnormal disynaptic I-a reciprocal inhibition is responsible for Parkinsonian rigidity. A neural model of Parkinson's disease bradykinesia is extended to incorporate the effects of spindle feedback on key cortical cells and examine the effects of dopamine depletion on spinal activities. Simulation results show that although reciprocal inhibition is reduced in DA depleted case, it doesn't lead to co-contraction of antagonist motor neurons. Implications to Parkinsonian rigidity are discussed.
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