Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 64, Issue 15, Pages 1970-1978Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-007-6514-3
Keywords
aldose reductase; aldehyde reductase; polyol pathway; glucose metabolism; enzyme inhibition; drug design; diabetes
Categories
Ask authors/readers for more resources
Aldose reductase and aldehyde reductase belong to the aldo-keto reductase superfamily of enzymes whose members are responsible for a wide variety of biological functions. Aldose reductase has been identified as the first enzyme involved in the polyol pathway of glucose metabolism which converts glucose into sorbitol. Glucose over-utilization through the polyol pathway has been linked to tissue-based pathologies associated with diabetes complications, which make the development of a potent aldose reductase inhibitor an obvious and attractive strategy to prevent or delay the onset and progression of the complications. Structural studies of aldose reductase and the homologous aldehyde reductase in complex with inhibitor were carried out to explain the difference in the potency of enzyme inhibition. The aim of this review is to provide a comprehensive summary of previous studies to aid the development of aldose reductase inhibitors that may have less toxicity problems than the currently available ones.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available