Journal
ONCOGENE
Volume 26, Issue 39, Pages 5752-5761Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.onc.1210359
Keywords
brain tumor; glioma; Hedgehog; cancer stem; cell; Olig2; patched
Funding
- NINDS NIH HHS [R01 NS051557, K08 NS02133] Funding Source: Medline
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The hedgehog (Hh) signaling pathway regulates progenitor cells during embryogenesis and tumorigenesis in multiple organ systems. We have investigated the activity of this pathway in adult gliomas, and demonstrate that the Hh pathway is operational and activated within grade II and III gliomas, but not grade IV de novo glioblastoma multiforme. Furthermore, our studies reveal that pathway activity and responsiveness is confined to progenitor cells within these tumors. Additionally, we demonstrate that Hh signaling in glioma progenitor cells is ligand-dependent and provide evidence documenting the in vivo source of Sonic hedgehog protein. These findings suggest a regulatory role for the Hh pathway in progenitor cells within grade II and III gliomas, and the potential clinical utility of monitoring and targeting this pathway in these primary brain tumors.
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