Journal
NEUROLOGIC CLINICS
Volume 25, Issue 3, Pages 669-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.ncl.2007.03.007
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Funding
- NINDS NIH HHS [5R01NS048554, R01 NS042192-03, R01 NS048554-02, R01 NS042192-02, 5R01NS042192, R01 NS048554-04, R01 NS042192, R01 NS048554, R01 NS042192-01A2, R01 NS048554-03, R01 NS048554-01] Funding Source: Medline
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Alzheimer's disease (AD) is a devastating neurodegenerative disease. To rationally develop novel therapeutic and/or preventative agents for AD, an understanding of the etiology and pathogenesis of this complex disease is necessary. This article examines the evidence for the amyloid hypothesis of AD pathogenesis and discusses how it relates to the neurological and neuropathological features of AD, the known genetic risk factors and causative mutations, and the heightened risk associated with advanced age.
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