Journal
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
Volume 55, Issue 8, Pages 831-843Publisher
HISTOCHEMICAL SOC INC
DOI: 10.1369/jhc.6A7145.2007
Keywords
sarcoglycan; smooth muscle; immunohistochemistry; RT-PCR; gastroenteric tract; vessels
Categories
Ask authors/readers for more resources
The sarcoglycan complex (SGC) is a multimember transmembrane complex interacting with other members of the dystrophin-glycoprotein complex (DGC) to provide a mechanosignaling connection from the cytoskeleton to the extracellular matrix. The SGC consists of four proteins (alpha, beta, gamma, and delta). A fifth sarcoglycan subunit, C-sarcoglycan, shows a wider tissue distribution. Recently, a novel sarcoglycan, the zeta-sarcoglycan, has been identified. All reports about the structure of SGC showed a common assumption of a tetrameric arrangement of sarcoglycans. Addressing this issue, our immunofluorescence and molecular results showed, for the first time, that all sarcoglycans are always detectable in all observed samples. Therefore, one intriguing possibility is the existence of a pentameric or hexameric complex considering zeta-sarcoglycan of SGC, which could present a higher or lower expression of a single sarcoglycan in conformity with muscle type-skeletal, cardiac, or smooth-or also in conformity with the origin of smooth muscle.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available