Journal
JOURNAL OF BONE AND MINERAL RESEARCH
Volume 22, Issue 8, Pages 1301-1310Publisher
WILEY
DOI: 10.1359/JBMR.070501
Keywords
Toll-like receptors; CpG-oligodeoxynucleotides; extracellular signal-related kinase; c-fos; osteoclasts
Categories
Ask authors/readers for more resources
CpG-ODN, in addition to stimulation of osteoclastogenic signals in early osteoclast precursors, also induces phosphatase, shifting the pattern of ERK phosphorylation from sustained to transient. This shift results in the degradation of c-fos, an essential molecule for osteoclast differentiation. Therefore, CpG-ODN blocks osteoclast differentiation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
