Journal
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
Volume 406, Issue 25, Pages 6095-6103Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00216-014-7930-5
Keywords
Chiral separation; Enantioselective(U)HPLC and SFC; Chiral stationary phase; Cinchona alkaloid; Quinine and quinidine carbamates; Amino acids
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This article provides a condensed introduction to principles of chiral separation, gives a historic overview of the genesis of the most important concepts regarding chiral stationary phase (CSPs), and summarizes the state of the art in a concise manner. Some recent developments in the field of polysaccharide CSPs are outlined. Finally, the article focusses on the new concept of zwitterionic chiral stationary phases and their application profile and peculiarities. Some other trends in column technology, including sub-2 mu m and core-shell CSP particles and the emerging field of (UP)SFC, are briefly discussed.
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