Journal
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
Volume 406, Issue 20, Pages 4825-4829Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00216-014-7936-z
Keywords
Bioanalytical methods; Drug-mimicking release; Immune sensing; Bioelectrocatalysis; Modified electrode
Funding
- NSF [CBET-1066397, DRM-1309469]
- Ministerio de Economia e Innovacion [CTQ2012-34238]
- Div Of Chem, Bioeng, Env, & Transp Sys
- Directorate For Engineering [1066397] Funding Source: National Science Foundation
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A new sense-and-act system was realized by integrating a biocatalytic/bioaffinity electrode responding to immune signals represented by an antibody and a polymer-modified electrode loaded with drug-mimicking species. The release of the drug-mimicking species was achieved specifically in response to a signal antibody, thus demonstrating for the first time an immune-induced drug-releasing process. The present approach promises new options for future applications in controlled drug release and personalized medicine.
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