Journal
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
Volume 406, Issue 25, Pages 6337-6346Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00216-014-8064-5
Keywords
p-Aminothiophenol; SERS; Multi-wall carbon nanotubes; pH sensor
Funding
- Natural Science Foundation of China (NSFC) [61177033, 21104009, 61275182]
- Science Foundation for the Excellent Youth Scholars of Southeast University
- Fundamental Research Funds for the Central Universities
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p-Aminothiophenol (pATP) functionalized multi-walled carbon nanotubes (MWCNTs) have been demonstrated as an efficient pH sensor for living cells. The proposed sensor employs gold/silver core-shell nanoparticles (Au@Ag NPs) functionalized MWCNTs hybrid structure as the surface-enhanced Raman scattering (SERS) substrate and pATP molecules as the SERS reporters, which possess a pH-dependent SERS performance. By using MWCNTs as the substrate to be in a state of aggregation, the pH sensing range could be extended to pH 3.0 similar to 14.0, which is much wider than that using unaggregated Au@Ag NPs without MWCNTs. Furthermore, the pH-sensitive performance was well retained in living cells with a low cytotoxicity. The developed SERS-active MWCNTs-based nanocomposite is expected to be an efficient intracellular pH sensor for bio-applications.
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