Journal
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
Volume 407, Issue 8, Pages 2321-2327Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00216-014-8210-0
Keywords
Imaging mass spectrometry; FTMS; Supercomputing; Cloud computing; Parallel processing; MALDI
Funding
- SURF Foundation
- Dutch national program COMMIT
- Department of Energy's Office of Biological and Environmental Research
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High-resolution Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometry imaging enables the spatial mapping and identification of biomolecules from complex surfaces. The need for long time-domain transients, and thus large raw file sizes, results in a large amount of raw data (big data) that must be processed efficiently and rapidly. This can be compounded by large-area imaging and/or high spatial resolution imaging. For FT-ICR, data processing and data reduction must not compromise the high mass resolution afforded by the mass spectrometer. The continuous mode Mosaic Datacube approach allows high mass resolution visualization (0.001 Da) of mass spectrometry imaging data, but requires additional processing as compared to feature-based processing. We describe the use of distributed computing for processing of FT-ICR MS imaging datasets with generation of continuous mode Mosaic Datacubes for high mass resolution visualization. An eight-fold improvement in processing time is demonstrated using a Dutch nationally available cloud service.
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