Journal
JOURNAL OF PHARMACEUTICAL SCIENCES
Volume 96, Issue 8, Pages 2048-2056Publisher
JOHN WILEY & SONS INC
DOI: 10.1002/jps.20850
Keywords
chlorhexidine diacetate; PEM/THFM; supercritical fluid; amorphous; controlled release
Funding
- Engineering and Physical Sciences Research Council [GR/A11304/01] Funding Source: researchfish
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The release of chlorhexidine diacetate (CX) from a self-curing polymeric system based on poly(ethylmethacrylate) and tetrahydrofurfurylmethacrylate (PEM/THFM) was developed in this study. Supercritical fluid assisted impregnation and foaming was employed for preparing porous CX-PEM/THFM drug release system. X-ray diffraction (XRD) and differential scanning calorimetry (DSC) show that the crystallinity of CX significantly decreased after supercritical processing, whilst Raman spectroscopy suggested a hydrogen bonding interaction between the CX and PEM in the product. A UV-Vis dissolution study revealed that the drug release rate is almost as seven times faster in the SCF processed drug delivery system than conventional cured samples. (c) 2007 Wiley-Liss, Inc.
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