Journal
NATURE GENETICS
Volume 39, Issue 8, Pages 977-983Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ng2062
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Funding
- FIC NIH HHS [3T37TW00041-03S2] Funding Source: Medline
- NCRR NIH HHS [RR03048] Funding Source: Medline
- NIDDK NIH HHS [DK072128] Funding Source: Medline
- Wellcome Trust Funding Source: Medline
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We performed a genome-wide association scan to search for sequence variants conferring risk of prostate cancer using 1,501 Icelandic men with prostate cancer and 11,290 controls. Follow-up studies involving three additional case-control groups replicated an association of two variants on chromosome 17 with the disease. These two variants, 33 Mb apart, fall within a region previously implicated by family-based linkage studies on prostate cancer. The risks conferred by these variants are moderate individually ( allele odds ratio of about 1.20), but because they are common, their joint population attributable risk is substantial. One of the variants is in TCF2 ( HNF1 beta), a gene known to be mutated in individuals with maturity-onset diabetes of the young type 5. Results from eight case-control groups, including one West African and one Chinese, demonstrate that this variant confers protection against type 2 diabetes.
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