Journal
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
Volume 106, Issue 1-5, Pages 24-30Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jsbmb.2007.05.012
Keywords
prospective; estrogens; testosterone; breast cancer; premenopausal; postmenopausal; epidemiology
Funding
- NCI NIH HHS [R01 CA067262-13, R01 CA067262, CA49449, R01 CA049449-19, U01 CA049449, CA67262, U01 CA067262, R01 CA049449] Funding Source: Medline
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Multiple lines of evidence support a central role of hormones in the etiology of breast cancer. In epidemiologic studies, considerable effort has focused on delineating the role of endogenous hormones in risk of breast cancer among postmenopausal women. Recently, substantial additional data has accrued from prospective studies where endogenous hormones are measured in study subjects prior to disease diagnosis. In this review, the epidemiologic evidence linking sex steroids-estrogens, testosterone, and progesterone, specifically-with subsequent risk of breast cancer in both premenopausal and postmenopausal women is summarized. Overall, a strong positive association between breast cancer risk and circulating levels of both estrogens and testosterone has now been well confirmed among postmenopausal women; women with hormone levels in the top 20% of the distribution (versus bottom 20%) have a two- to three-fold higher risk of breast cancer. Evidence among premenopausal women is more limited, though increased risk associated with higher levels of testosterone is consistent. However, both positive and null associations have been observed with estrogens and progesterone and clearly more evaluation is needed. (C) 2007 Elsevier Ltd. All rights reserved.
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