Journal
HUMAN PATHOLOGY
Volume 38, Issue 8, Pages 1137-1144Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.humpath.2007.04.015
Keywords
FISH; fluorescence in situ hybridization; cytology; bladder cancer; biliary tract; lung cancer; Barrett's esophagus
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Fluorescence in situ hybridization (FISH) is a technique that uses fluorescently labeled DNA probes to detect chromosomal alterations in cells. FISH can detect various types of cytogenetic alterations including aneusomy (ie, abnormalities of chromosome copy number), duplication, amplification, deletion, and translocation. Because tumor cells generally contain chromosomal alterations, FISH is able to detect cells that have chromosomal abnormalities consistent with neoplasia in exfoliative and aspiration cytology specimens. This review will discuss the utility of FISH for the detection of bladder, lung, pancreatobiliary, and esophageal carcinoma in cytologic specimens. (c) 2007 Elsevier Inc. All rights reserved.
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