Journal
EXPERIMENTAL NEUROLOGY
Volume 206, Issue 2, Pages 288-295Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.expneurol.2007.05.007
Keywords
amyotrophic lateral sclerosis; glatiramer acetate; copaxone (R); Cu/Zn-superoxide dismutase; SOD1-G93A
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In amyotrophic lateral sclerosis (ALS), an involvement of the immune system in the degenerative processes has been shown in both humans and the transgenic SOD1-G93A mice. We previously showed that Glatiramer acetate (also known as copolymer-1; COP-1; Copaxone((R))) improves motor function and extends survival times in an inbred strain of ALS mice probably by interacting with pro-inflammatory T-H lymphocytes. In the course of this study we tested whether these beneficial effects could be reproduced by repeated vaccination of animals with COP-1 without co-administration of complete Freund's adjuvant. In an outbred strain we could not demonstrate a positive effect of COP-1 on survival times, but found a significant improvement of motor performance during the late stage of disease and a moderate decrease of the production of the inflammatory cytokines interferon-gamma and IL-4 by T lymphocytes isolated from the mice's spleen. In conclusion, the effects of COP-1 in the applied hybrid strain displaying a faster disease progression were less pronounced than in the earlier tested inbred strain of ALS mice. (c) 2007 Elsevier Inc. All rights reserved.
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