Journal
TISSUE ENGINEERING
Volume 13, Issue 8, Pages 1799-1808Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/ten.2006.0165
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The perspective of an innovative new concept integrating tissue- engineering techniques with an established surgical technique is described. The focus is primarily on a one- step surgical procedure using adipose tissue - derived mesenchymal stem cells, a calcium phosphate scaffold as a carrier, and a bioresorbable polymer cage to facilitate spinal interbody fusion. We address the harvesting and processing of clinically relevant quantities of adipose tissue - derived mesenchymal stem cells, triggering of these stem cells toward lineage- specific differentiation, seeding of the triggered stem cells on a bioresorbable scaffold, and implantation of the resulting tissue- engineered construct. The integrated steps can be accomplished within one surgical procedure in a surgical theater. Although the proposed concept has been developed for spinal fusion, potential application in other surgical disciplines is presumed realistic.
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