Journal
BRITISH JOURNAL OF NEUROSURGERY
Volume 21, Issue 4, Pages 396-398Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/02688690701400775
Keywords
atheroma; carotid; FEA; macrophage; MRI; stress
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High resolution, USPIO-enhanced MR imaging can be used to identify inflamed atherosclerotic plaque. We report a case of a 79-year-old man with a symptomatic carotid stenosis of 82%. The plaque was retrieved for histology and finite element analysis (FEA) based on the preoperative MR imaging was used to predict maximal Von Mises stress on the plaque. Macrophage location correlated with maximal predicted stresses on the plaque. This supports the hypothesis that macrophages thin the fibrous cap at points of highest stress, leading to an increased risk of plaque rupture and subsequent stroke.
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