Journal
CURRENT OPINION IN STRUCTURAL BIOLOGY
Volume 17, Issue 4, Pages 437-443Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2007.07.002
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Funding
- NIBIB NIH HHS [R01 EB000303-06] Funding Source: Medline
- NIDDK NIH HHS [R01 DK056212, R01 DK056212-06, DK-56212] Funding Source: Medline
- NINDS NIH HHS [R01 NS039918, NS-39918] Funding Source: Medline
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Secretion is a fundamental cellular process involving the regulated release of intracellular products from cells. Physiological functions such as neurotransmission, or the release of hormones and digestive enzymes, are all governed by cell secretion. Three critical activities occur at the cell plasma membrane to ensure secretion. Membrane-bound secretory vesicles dock, fuse, and expel their contents to the outside via specialized and permanent plasma membrane structures, called porosomes or fusion pores. In recent years, significant progress has been made in our understanding of these three key cellular activities required for cell secretion. The molecular machinery and mechanism involving them is summarized in this article.
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