Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 188, Issue 1-2, Pages 95-102Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2007.06.013
Keywords
Opioids; CD4(+) T cells; cell proliferation; lymph nodes; mice
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A number of studies have been dedicated to estimate the consequences on immunity of the clinical use of opioids by focusing on mitogen-induced polyclonal proliferation of T cells from blood or spleen. Here we examined, under physiological conditions, the contribution of endogenous opioids in the development of a CD4(+) T cell response within draining lymph nodes. We show in OVA-primed DOI 11.10 mice that delta-opioid receptors were upregulated upon Tcell activation in vivo and that opioid receptor neutralization increased the number of specific anti-OVAT lymphocytes without promoting their capacity to proliferate. The sensitivity to Fas-mediated apoptosis of T lymphocytes and the synthesis of homeostatic lymphoid chernokines were not either affected suggesting that opioids operate mainly before the entry of T lymphocytes into lymph nodes. (c) 2007 Elsevier B.V. All rights reserved.
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