Journal
JOURNAL OF BONE AND MINERAL RESEARCH
Volume 22, Issue 8, Pages 1224-1233Publisher
WILEY
DOI: 10.1359/JBMR.070414
Keywords
stem cells; cord blood; bone healing; rodent; transplantation
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Stem cell and tissue engineering-based therapies have become a promising option to heal bony defects in the future. Human cord blood-derived mesenchymal stem cells were seeded onto a collagen/tricalcium phosphate scaffold and xenotransplanted into critical size femoral defects of 46 nude rats. We found a survival of human cells within the scaffold and surrounding bone/bone marrow up to 4 wk after transplantation and an increased bone healing rate compared with controls without stem cells. This study supports the application of cord blood stem cells for bone regeneration.
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