Journal
JOURNAL OF CUTANEOUS PATHOLOGY
Volume 34, Issue 8, Pages 593-596Publisher
BLACKWELL PUBLISHING
DOI: 10.1111/j.1600-0560.2006.00675.x
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Funding
- NCI NIH HHS [R01 CA098807-04, R01 CA098807, R01 CA116021-03, R01 CA116021] Funding Source: Medline
- BLRD VA [IK6 BX005225] Funding Source: Medline
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Background: Activated Akt expression (p-Akt) is reportedly increased in many melanomas as compared with benign nevi. The purpose of this study was to evaluate and compare p-Akt immunohistological staining in benign nevi, Spitz nevi and primary melanomas. Methods: Immunostaining for phosphorylated Akt was performed in 41 melanocytic lesions previously classified as benign intradermal nevus (14 lesions), Spitz nevus (9 lesions) or melanoma (18 lesions). Lesions were graded for intensity of p-Akt staining by two independent observers (0, no staining; 1, slightly positive; 2, moderately positive; 3, highly positive). Scores were averaged, and statistical analyses were performed. Results: Benign nevi showed less staining (mean score 1. 18) compared with Spitz nevi (mean score 2.11) and melanomas (mean score 2.19). This difference was statistically significant between benign nevi and melanomas (p = 0.0047) and benign nevi and Spitz nevi (p = 0.02 7 1). No statistical difference was detected in staining between Spitz nevi and melanomas (p = 0.8309). Conclusions: Activated Akt expression is increased in Spitz nevi and melanomas as compared with benign intradermal nevi, but is unlikely to prove useful in differentiating between the former.
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