Pre-exposure rabies vaccination using purified chick embryo cell rabies vaccine intradermally is immunogenic and safe

Objective To demonstrate the safety and immunogenicity of intradermal rabies pre-exposure prophylaxis with purified chick embryo cell vaccine (PCECV) in schoolchildren age 5 to 8 years in Thailand. Study design In a randomized, open-label, phase 11 clinical trial, 2 or 3 intradermal doses of 0.1 mL PCECV (Rabipur (R)) were administered to 703 schoolchildren on days 0 and 28 or on days 0, 7, and 28. In 206 children, 2 simulated post-exposure booster doses were given I year after the primary vaccination series. Rabies virus- neutralizing antibody (RVNA) titers were determined by the rapid fluorescent focus inhibition test. Results In school-age children in Thailand, a pre-exposure immunization regimen of 3 intradermal doses of PCECV produced adequate immune. responses. After primary vaccination, all subjects developed RVNA titers 2tt)>= 0.5 IU/mL and demonstrated a rapid increase in RVNA titer after 2 simulated post-exposure booster immunizations I year after the primary vaccination series. No serious adverse drug reactions occurred. Conclusions Rabies pre-exposure immunization with PCECV is safe and immunogenic, and its implementation could save the fives of many children in rabies-endemic areas.