Journal
AGEING RESEARCH REVIEWS
Volume 6, Issue 2, Pages 128-140Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.arr.2007.04.001
Keywords
sir2-family; calorie restriction; life span; sirtuins; dietary restriction; caloric restriction; aging
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Funding
- NIA NIH HHS [P30 AG013280] Funding Source: Medline
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Activation of Sir2-family proteins in response to calorie restriction (CR) has been proposed as an evolutionarily conserved mechanism for life span extension. This idea has been called into question with the discovery that Sir2-family proteins are not required for life span extension from CR in yeast. We present here a historical perspective and critical evaluation of the model that CR acts through Sir2 in yeast, and interpret prior reports in light of more recent discoveries. Several specific cases where the Sir2 model of CR is inconsistent with experimental data are noted. These shortcomings must be considered along with evidence supporting a role for Sir2 in CR in order to fully evaluate the validity of this model. (c) 2007 Elsevier Ireland Ltd. All rights reserved.
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