Journal
SEMINARS IN FETAL & NEONATAL MEDICINE
Volume 12, Issue 4, Pages 250-258Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.siny.2007.01.015
Keywords
development; erythropoietin; G-CSF; growth factor; neonatal brain injury; neurogenesis; neuroprotection
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Funding
- NCRR NIH HHS [M01 RR000082, M01 RR000082-380713] Funding Source: Medline
- NICHD NIH HHS [R21 HD042213, R21 HD042213-03] Funding Source: Medline
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The growth factors erythropoietin and granulocyte-colony stimulating factor have hematopoietic and non-hematopoietic functions. Both are used clinically in their recombinant forms. Both also have interesting tissue-protective effects in other organs, which are unrelated to their hematopoietic functions. They have clinical hematopoietic uses in neonatal populations and in experimental non-hematopoietic research, and clinical potential as neuroprotective or tissue-protective agents. (C) 2007 Elsevier Ltd. All rights reserved.
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