Journal
COMPUTATIONAL BIOLOGY AND CHEMISTRY
Volume 31, Issue 4, Pages 239-245Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.compbiolchem.2007.03.013
Keywords
gene networks; inference; optimization; ordinary differential equations; noise; time-delay
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Ordinary differential equations (ODE) have been widely used for modeling and analysis of dynamic gene networks in systems biology. In this paper, we propose an optimization method that can infer a gene regulatory network from time-series gene expression data. Specifically, the following four cases are considered: (1) reconstruction of a gene network from synthetic gene expression data with noise, (2) reconstruction of a Dene network from synthetic gene expression data with time-delay, (3) reconstruction of a gene network from synthetic gene expression data with noise and time-delay, and (4) reconstruction of a gene network from experimental time-series data in budding yeast cell cycle. (c) 2007 Elsevier Ltd. All rights reserved.
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