Journal
NATURE GENETICS
Volume 39, Issue 8, Pages 966-968Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ng2065
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The spindle assembly checkpoint guards against chromosomal missegregation but does not induce arrest in oocytes that contain a few achiasmatic chromosomes ( univalents). We followed the fate of univalents in oocytes during the first meiotic division, and although these preserved a meiotic kinetochore structure, they were also bi-oriented in a mitotic manner. The hybrid chromosomal configuration attained by univalents allows them to evade the spindle assembly checkpoint and contribute to aneuploidy in oocytes.
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