Journal
BIOMATERIALS
Volume 28, Issue 24, Pages 3537-3548Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2007.04.026
Keywords
endotheliat cells; ePTFE vascular grafts; surface modification; platelet adhesion
Funding
- NCATS NIH HHS [TL1 TR000441] Funding Source: Medline
- NIBIB NIH HHS [R01 EB002067-17, R01 EB002067, R01 EB002067-18, 5R01EB002067, R01 EB002067-15A1, R01 EB002067-16] Funding Source: Medline
- NIGMS NIH HHS [5T32GM007250, T32 GM007250] Funding Source: Medline
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Endothelialization of expanded polytetrafluoroethylene (ePTFE) has the potential to improve long-term patency for small-diameter vascular grafts. Successful endothelialization requires ePTFE surface modification to permit cell attachment to this otherwise non-adhesive substrate. We report here on a peptide fluorosurfactant polymer (FSP) biomimetic construct that promotes endothelial cell (EC)-selective attachment. growth, shear stability, and function on ePTFE. The peptide FSP consists of a flexible poly(vinyl amine) backbone with EC-selective peptide ligands for specific cell adhesion and pendant fluorocarbon branches for stable anchorage to underlying ePTFE. The EC-selective peptide (primary sequence: Cys-Arg-Arg-Glu-Thr-Ala-Trp-Ala-Cys, CRRETAWAC) has demonstrated high binding affinity for the alpha(5)beta(1) integrin found on ECs. Here, we demonstrate low affinity of CRRETAWAC for platelets and platelet integrins, thus providing it with EC-selectivity. This EC-selectivity could potentially facilitate rapid in vivo endothelialization and healing without thrombosis for small-diameter ePTFE vascular grafts. (c) 2007 Elsevier Ltd. All rights reserved.
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