Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2007, Issue 24, Pages 4065-4075Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.200700320
Keywords
aldol reactions; boron; regioselectivity; ketones; solvent effects
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The regioselectivity of the Chx(2)BCl/Et3N-mediated (Chx = cyclohexyl) aldol reactions of ketones of general structure 2 has been studied and was shown to depend on both ketone structure and solvent. Useful levels of regioselectivity in favour of any of the two possible regioisomers were obtained in either pentane or diethyl ether. The relative configuration of the aldol products was assigned by H-1 NMR studies of six-membered-ring derivatives. ((c) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007).
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