[11C]Carbon monoxide, a versatile and useful precursor in labelling chemistry for PET ligand development

In this review the recent progress in the development of suitable precursors for C-11-labelling is discussed. Especially the last few years' advancement of the use of [C-11] carbon monoxide as a versatile and useful precursor in labelling chemistry is presented. The development is set in perspective of its potential in applying molecular imaging tools in drug and tracer development. The possibility of exploring small tracer libraries utilizing the microdosing concept is explored. Copyright (c) 2007 John Wiley & Sons, Ltd.