Journal
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
Volume 403, Issue 6, Pages 1491-1500Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00216-012-5944-4
Keywords
Sulfotransferases; Sulfonation; Carbohydrates; Enzyme assays; Peptides
Funding
- National Institutes of Health [GM38060, HL094463, HL096972]
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Sulfotransferases are enzymes that catalyze the transfer of sulfo groups from a donor, for example 3'-phosphoadenosine 5'-phosphosulfate, to an acceptor, for example the amino or hydroxyl groups of a small molecule, xenobiotic, carbohydrate, or peptide. These enzymes are important targets in the design of novel therapeutics for treatment of a variety of diseases. This review examines assays used for this important class of enzyme, paying particular attention to sulfotransferases acting on carbohydrates and peptides and the major challenges associated with their analysis.
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