Journal
JOURNAL OF CLINICAL INVESTIGATION
Volume 117, Issue 8, Pages 2044-2050Publisher
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI32810
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Funding
- NCI NIH HHS [T32 CA009056, T32 CA09056] Funding Source: Medline
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Peter Nowell and David Hungerford's discovery of the Philadelphia chromosome facilitated many critical studies that have led to a paradigm shift in our understanding of cancer as a disease of stem cells. This Review focuses on the application of these concepts to investigation of the role of stem cells in prostate cancer initiation and progression. Major strides in the development of in vitro and in vivo assays have enabled identification and characterization of prostate stem cells as well as functional evaluation of the tumorigenic effects of prostate cancer-related genetic alterations.
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