Journal
NATURE REVIEWS NEUROSCIENCE
Volume 8, Issue 8, Pages 597-609Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrn2191
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Funding
- NIMH NIH HHS [MH64070] Funding Source: Medline
- NINDS NIH HHS [NS24067, R01 NS27337, R01 NS50944] Funding Source: Medline
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The properties of synaptic transmission were first elucidated at the neuromuscular junction. More recent work has examined transmission at synapses within the brain. Here we review the remarkable progress in understanding the biophysical and molecular basis of the sequential steps in this process. These steps include the elevation of Ca2+ in microdomains of the presynaptic terminal, the diffusion of transmitter through the fusion pore into the synaptic cleft and the activation of postsynaptic receptors. The results give insight into the factors that control the precision of quantal transmission and provide a framework for understanding synaptic plasticity.
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