Journal
JOURNAL OF VIROLOGY
Volume 81, Issue 16, Pages 8827-8832Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.00895-07
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Funding
- Intramural NIH HHS Funding Source: Medline
- NCI NIH HHS [N01CO12400] Funding Source: Medline
- NCRR NIH HHS [C06 RR015459, P51 RR 000167, C06 RR020141, R24 RR 015371, R24 RR015371, P51 RR000167, R24 RR 016038, R24 RR016038, RR 15459-01, RR 020141-01] Funding Source: Medline
- NIAID NIH HHS [R01 AI049120, R01 AI052056, R01 AI 052056, R01 AI 049120] Funding Source: Medline
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Certain major histocompatibillity complex (MHC) class I allelles are associated with the control of human immunodeficiency virus and simian immunodeficiency virus (SIV) replication. We have designed sequence-specific primers for detection of the rhesus macaque MHC class I allele Mamu-B*08 by PCR and screened a cohort of SIV-infected macaques for this allele. Analysis of 196 SIVmac,239-infected Indian rhesus macaques revealed that Mamu-B*08 was significantly overrepresented in elite controllers; 38% of elite controllers were Mamu-B*08 positive compared to 3% of progressors (P = 0.00001). Mamu-B*08 was also associated with a 7.34-fold decrease in chronic phase viremia (P = 0.002). Mamu-B*08-positive macaques may, therefore, provide a good model to understand the correlates of MHC class I allele-associated immune protection and viral containment in human elite controllers.
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