Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 17, Issue 15, Pages 4102-4106Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2007.05.065
Keywords
amphiphilic cationic; quinine-derived; antibacterial activity; MRSA
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Several representative amphiphilic cationic quinine-derived have been synthesized and evaluated against methicillin-resistant Staphylococcus aureus. This is the first reported antibacterial activity of this class of compounds. In vitro the minimal inhibitory concentration values of the best compound Q7 ranged from 0.4 to 1.6 mu g/mL (MBC < 3.2 mu g/mL). (K) 2007 Elsevier Ltd. All rights reserved.
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