Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 8, Issue 8, Pages 622-632Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm2217
Keywords
-
Categories
Funding
- MRC [G9310915] Funding Source: UKRI
- Medical Research Council [G9310915] Funding Source: Medline
- Wellcome Trust Funding Source: Medline
- Medical Research Council [G9310915] Funding Source: researchfish
Ask authors/readers for more resources
Lysosomes are dynamic organelles that receive and degrade macromolecules from the secretory, endocytic, autophagic and phagocytic membrane- trafficking pathways. Live-cell imaging has shown that fusion with lysosomes occurs by both transient and full fusion events, and yeast genetics and mammalian cell-free systems have identified much of the protein machinery that coordinates these fusion events. Many pathogens that hijack the endocytic pathways to enter cells have evolved mechanisms to avoid being degraded by the lysosome. However, the function of lysosomes is not restricted to protein degradation: they also fuse with the plasma membrane during cell injury, as well as having more specialized secretory functions in some cell types.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available