Journal
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
Volume 403, Issue 8, Pages 2203-2212Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00216-012-5891-0
Keywords
Raman optical activity; ROA; Peptide conformation; Solution structure; Amyloid fibril
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Recent developments of vibrational Raman optical activity (ROA) spectroscopy enabled the detailed analyses of the backbone and side chain conformations of peptides and proteins in solution phases. ROA can be used as a powerful analytical technique for determining not only the structures of conformers, but also their populations even for systems in fast conformational equilibria where NMR spectroscopy is difficult to be applied. ROA enabled the monitoring of the secondary structures of denatured or unfolded proteins, such as an amyloid fibril and its prefibril intermediates.
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