Journal
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
Volume 402, Issue 2, Pages 593-600Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00216-011-5340-5
Keywords
Carbon nanoparticles; Lateral flow assays; Protein microarray-based assays; Nucleic acid immunoassays (DNA/RNA); Immunochemical assays; Diagnostics
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Carbon nanoparticles (CNPs) labeled with reporter molecules can serve as signaling labels in rapid diagnostic assays as an alternative to gold, colored latex, silica, quantum dots, or up-converting phosphor nanoparticles. Detailed here is the preparation of biomolecule-labeled CNPs and examples of their use as a versatile label. CNPs can be loaded with a range of biomolecules, such as DNA, antibodies, and proteins (e.g., neutravidin or a fusion protein of neutravidin with an enzyme), and the resulting conjugates can be used to detect analytes of high or low molecular mass.
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