Journal
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
Volume 402, Issue 2, Pages 601-623Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00216-011-5120-2
Keywords
Laser desorption ionization; Mass spectrometry; Gold nanomaterial; SALDI; SELDI; NALDI
Funding
- Italian Project Nanomaterials and laser ionization mass spectrometry: a new bio-analytical approach
- Ministero dell'Istruzione, dell'Universita della Ricerca
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Nanomaterials have emerging importance in laser desorption ionization mass spectrometry (LDI-MS) with the ultimate objective being to overcome some of the most important limitations intrinsically related to the use of conventional organic matrices in matrix-assisted (MA) LDI-MS. This review provides a critical overview of the most recent literature on the use of gold nanomaterials as non-conventional desorption ionization promoters in LDI-MS, with particular emphasis on bioanalytical applications. Old seminal papers will also be discussed to provide a timeline of the most significant achievements in the field. Future prospects and research needs are also briefly discussed.
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