Journal
NANO LETTERS
Volume 7, Issue 8, Pages 2513-2520Publisher
AMER CHEMICAL SOC
DOI: 10.1021/nl071611t
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Astrocytes are the principle macroglial brain cells. They are activated by different stressors and brain injuries. Quantum dots (QDs) can cause oxidative stress. This study shows a real-time imaging of primary cortical cultures and assessment of QD-induced activation of astrocytes in the brains of transgenic mice with the luciferase gene driven by the murine astrocyte promoter. This approach may be widely applicable for assessing the astroglia/tissue response to nanoparticles in live animals.
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